[N-(3-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine

Base Information

• Chemical Name: [N-(3-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine
• CAS No.: 1227277-39-5
• Molecular Formula: C₂₃H₂₇N₃O
• Molecular Weight: 361.487
• Mol file: 1227277-39-5.mol

Synonyms:[N-(3-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine

Chemical Property of [N-(3-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [N-(3-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine

There total 5 articles about [N-(3-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-tert-butyl-2-hydroxybenzyl bromide (1072238-39-1) + bis[(2-pyridyl)methyl]amine (1539-42-0) → [N-(3-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine (1227277-39-5)

Guidance literature:

3-tert-butyl-2-hydroxybenzyl bromide; bis[(2-pyridyl)methyl]amine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With triethylamine; In tetrahydrofuran; Reflux; Inert atmosphere;

DOI:10.1016/j.ica.2009.12.039

Reference yield: 55.0%

pyridine-2-carbaldehyde (1121-60-4) + 2-(3-tert-butyl-2-hydroxybenzyl)aminomethylpyridine (189139-14-8) → [N-(3-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine (1227277-39-5)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 24h; Cooling with ice;

DOI:10.1039/c7dt01716b

Reference yield:

2-tert-Butylphenol (88-18-6) → [N-(3-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine (1227277-39-5)

Guidance literature:

Multi-step reaction with 4 steps

1: magnesium chloride; triethylamine / tetrahydrofuran / 12 h / Reflux

2: methanol / 20 °C

3: sodium tetrahydroborate / methanol / 12 h / 20 °C / Cooling with ice

4: acetic acid; sodium cyanoborohydride / methanol / 24 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; sodium cyanoborohydride; acetic acid; triethylamine; magnesium chloride; In tetrahydrofuran; methanol;

DOI:10.1039/c7dt01716b

upstream raw materials:

3-tert-butyl-2-hydroxybenzyl bromide

bis[(2-pyridyl)methyl]amine

3-tert-butyl-2-hydroxybenzaldehyde

2-tert-Butylphenol