2-(2-{(1S,2R)-2-[(E)-2-(2,6-Dimethoxy-4-methyl-phenyl)-vinyl]-2,6,6-trimethyl-cyclohexyl}-ethyl)-2-methyl-[1,3]dioxolane

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Chemical Name:2-(2-{(1S,2R)-2-[(E)-2-(2,6-Dimethoxy-4-methyl-phenyl)-vinyl]-2,6,6-trimethyl-cyclohexyl}-ethyl)-2-methyl-[1,3]dioxolane
CAS No.:132969-37-0
Molecular Formula:C₂₆H₄₀O₄
Molecular Weight:416.601
Hs Code.:

Synonyms:2-(2-{(1S,2R)-2-[(E)-2-(2,6-Dimethoxy-4-methyl-phenyl)-vinyl]-2,6,6-trimethyl-cyclohexyl}-ethyl)-2-methyl-[1,3]dioxolane

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Chemical Property of 2-(2-{(1S,2R)-2-[(E)-2-(2,6-Dimethoxy-4-methyl-phenyl)-vinyl]-2,6,6-trimethyl-cyclohexyl}-ethyl)-2-methyl-[1,3]dioxolane

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Technology Process of 2-(2-{(1S,2R)-2-[(E)-2-(2,6-Dimethoxy-4-methyl-phenyl)-vinyl]-2,6,6-trimethyl-cyclohexyl}-ethyl)-2-methyl-[1,3]dioxolane

There total 14 articles about 2-(2-{(1S,2R)-2-[(E)-2-(2,6-Dimethoxy-4-methyl-phenyl)-vinyl]-2,6,6-trimethyl-cyclohexyl}-ethyl)-2-methyl-[1,3]dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 132969-36-9
r-1-<(E)-2-(2,6-dimethoxy-4-methylphenyl)ethenyl>-t-2-(3-oxobutyl)-1,3,3-trimethylcyclohexane

: 107-21-1
ethylene glycol

: 132969-37-0
2-(2-{(1S,2R)-2-[(E)-2-(2,6-Dimethoxy-4-methyl-phenyl)-vinyl]-2,6,6-trimethyl-cyclohexyl}-ethyl)-2-methyl-[1,3]dioxolane

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 5h; Heating;
DOI:10.1246/bcsj.64.50

Reference yield:

: 123298-86-2,123298-87-3,133007-85-9,133007-86-0
1β-<(tetrahydropyranyloxy)methyl>-5,5,8aβ-trimethyl-4aα,5,6,7,8,8a-hexahydro-2(1H)-naphthalenone

: 132969-37-0
2-(2-{(1S,2R)-2-[(E)-2-(2,6-Dimethoxy-4-methyl-phenyl)-vinyl]-2,6,6-trimethyl-cyclohexyl}-ethyl)-2-methyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / H₂ / 10 percent Pd/C / dioxane

2: 2.) pyridinium p-toluenesulfonate / 1.) Et₂O, -60 deg C; 2.) MeOH

3: 53 percent / NCS, Me₂S / toluene

4: 92 percent / BuLi / 1,2-dimethoxy-ethane

5: 98 percent / pyridinium chloride / CH₂Cl₂ / Ambient temperature

6: 91 percent

With N-chloro-succinimide; n-butyllithium; dimethylsulfide; hydrogen; pyridine hydrochloride; pyridinium p-toluenesulfonate; palladium on activated charcoal; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1246/cl.1989.61

Reference yield:

: 123298-85-1,124753-29-3,133007-84-8
1α-hydroxymethyl-5,5,8aβ-trimethyl-4aα,5,6,7,8,8a-hexahydro-2(1H)-naphthalenone

: 132969-37-0
2-(2-{(1S,2R)-2-[(E)-2-(2,6-Dimethoxy-4-methyl-phenyl)-vinyl]-2,6,6-trimethyl-cyclohexyl}-ethyl)-2-methyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 8 steps

1: pyridinium p-toluenesulfonate

2: 45 percent / LDA, 10 percent citric acid / tetrahydrofuran / -78 °C

3: 95 percent / H₂ / 10 percent Pd/C / dioxane

4: 2.) pyridinium p-toluenesulfonate / 1.) Et₂O, -60 deg C; 2.) MeOH

5: 53 percent / NCS, Me₂S / toluene

6: 92 percent / BuLi / 1,2-dimethoxy-ethane

7: 98 percent / pyridinium chloride / CH₂Cl₂ / Ambient temperature

8: 91 percent

With N-chloro-succinimide; n-butyllithium; dimethylsulfide; hydrogen; pyridine hydrochloride; pyridinium p-toluenesulfonate; citric acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1246/cl.1989.61