(2,6-dibromophenyl) (2-chloropropyl) ether

Base Information

• Chemical Name: (2,6-dibromophenyl) (2-chloropropyl) ether
• CAS No.: 1001671-65-3
• Molecular Formula: C₉H₉Br₂ClO
• Molecular Weight: 328.431
• Mol file: 1001671-65-3.mol

Synonyms:(2,6-dibromophenyl) (2-chloropropyl) ether

Chemical Property of (2,6-dibromophenyl) (2-chloropropyl) ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2,6-dibromophenyl) (2-chloropropyl) ether

There total 2 articles about (2,6-dibromophenyl) (2-chloropropyl) ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,6-dibromophenol (608-33-3) + 1.3-chlorobromopropane (109-70-6) → (2,6-dibromophenyl) (2-chloropropyl) ether (1001671-65-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 21h;

DOI:10.1002/chem.201501959

Reference yield: 49.0%

2,6-dibromophenol (608-33-3) + 1,3-Dichloropropane (142-28-9) → (2,6-dibromophenyl) (2-chloropropyl) ether (1001671-65-3)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In acetonitrile; at 45 ℃; for 20h;

DOI:10.1002/adsc.200600478

Reference yield: 82.0%

(2,6-dibromophenyl) (2-chloropropyl) ether (1001671-65-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 8-formyl-3,4-dihydro-2H-1-benzopyran (327183-32-4)

Guidance literature:

(2,6-dibromophenyl) (2-chloropropyl) ether; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -43 ℃; for 1.25h; Schlenk technique; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at 20 ℃; for 1h; Schlenk technique; Inert atmosphere; Cooling with ice;

DOI:10.1002/chem.201501959

upstream raw materials:

2,6-dibromophenol

1,3-Dichloropropane

1.3-chlorobromopropane

Downstream raw materials:

8-formyl-3,4-dihydro-2H-1-benzopyran

Refernces

• 1、 Bieszczad, Bartosz,Barbasiewicz, Micha?. "The Key Role of the Nonchelating Conformation of the Benzylidene Ligand on the Formation and Initiation of Hoveyda-Grubbs Metathesis Catalysts". supporting information. p. 10322 - 10325. Retrieved 2015/07/07.