tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate

Base Information

Chemical Name:tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate
CAS No.:1181285-56-2
Molecular Formula:C₂₁H₃₅N₃O₂
Molecular Weight:361.528
Hs Code.:

Synonyms:tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate

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Chemical Property of tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate

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Technology Process of tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate

There total 6 articles about tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 123387-72-4
O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate

: 46367-53-7
N,N-dimethyl-4-phenylpiperidin-4-amine

: 1181285-56-2
tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate

Guidance literature:: O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate; N,N-dimethyl-4-phenylpiperidin-4-amine; With methanol; sodium cyanoborohydride; at 0 - 20 ℃;

With acetic acid; In methanol; at 20 ℃; for 12h; pH=~ 5;

With sodium cyanoborohydride; acetic acid; In methanol; for 0.75h;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1181285-56-2
tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / iodine / diethyl ether / 2.58 h

1.2: 80 °C

1.3: 0 °C / Saturated solution

2.1: 20 °C

2.2: 0 °C / Saturated solution

3.1: ethanol; potassium hydroxide / 48 h / Reflux

4.1: sodium cyanoborohydride / methanol / 0 - 20 °C

4.2: 20 °C / pH ~ 5

With ethanol; sodium cyanoborohydride; magnesium; potassium hydroxide; iodine; In methanol; diethyl ether;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1181285-56-2
tert-Butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)-carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / methanol; water / 0 - 20 °C

2.1: magnesium / iodine / diethyl ether / 2.58 h

2.2: 80 °C

2.3: 0 °C / Saturated solution

3.1: 20 °C

3.2: 0 °C / Saturated solution

4.1: ethanol; potassium hydroxide / 48 h / Reflux

5.1: sodium cyanoborohydride / methanol / 0 - 20 °C

5.2: 20 °C / pH ~ 5

With hydrogenchloride; ethanol; sodium cyanoborohydride; magnesium; potassium hydroxide; iodine; In methanol; diethyl ether; water;