tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butanoate

Base Information

Chemical Name:tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butanoate
CAS No.:1369963-05-2
Molecular Formula:C₃₀H₃₂N₂O₇S
Molecular Weight:564.659
Hs Code.:

Synonyms:tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butanoate

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Chemical Property of tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butanoate

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Technology Process of tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butanoate

There total 7 articles about tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-44-9
phthalic anhydride

: 1369963-05-2
tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / toluene / 18 h / 110 °C

2.1: bromine; phosphorus / tetrachloromethane / 9 h / 60 °C

3.1: dmap / tetrahydrofuran / 18 h / 20 °C

4.1: potassium carbonate / acetonitrile / 0.25 h / 20 °C

4.2: 56 h / 80 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4.5 h / 105 °C

With dmap; phosphorus; bromine; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1369963-04-1
tert-butyl 2-[(4-bromophenyl)(methylsulfonyl)amino]-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate

: 5720-07-0
4-methoxyphenylboronic acid

: 1369963-05-2
tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butanoate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 105 ℃; for 4.5h;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1369963-05-2
tert-butyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 1 h

2.1: potassium carbonate / acetonitrile / 0.25 h / 20 °C

2.2: 56 h / 80 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4.5 h / 105 °C

With pyridine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;