Technology Process of (3aR,6R,6aR)-5-(4-Methoxy-benzoyl)-6-methoxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-one
There total 21 articles about (3aR,6R,6aR)-5-(4-Methoxy-benzoyl)-6-methoxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium cerium(IV) nitrate;
In
acetonitrile;
DOI:10.1021/ja992135e
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 72 percent / TsOH
2: LDA
3: aq. H2O2
4: OsO4; NMO
5: TsOH / acetone
6: 73 percent / NH2NH2; 10 percent Pd/C / methanol / Heating
7: NaH / tetrahydrofuran; dimethylformamide
8: H2 / Pd(OH)2 / ethanol / 2585.74 Torr
9: 97 percent / NaH / tetrahydrofuran; dimethylformamide
10: 24 percent / aq. cerium(IV) ammonium nitrate / acetonitrile
With
palladium on activated charcoal; osmium(VIII) oxide; N-methyl-2-indolinone; ammonium cerium(IV) nitrate; hydrogen; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; hydrazine; lithium diisopropyl amide;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetone; acetonitrile;
1: Cyclization / 2: Metallation / 2: selenylation / 3: oxidative olefination / 4: Oxidation / 5: transacetalization / 6: Ring cleavage / 7: protection / 8: Hydrogenolysis / 9: Methylation / 10: deprotection;
DOI:10.1021/ja992135e
- Guidance literature:
-
Multi-step reaction with 13 steps
1: SOCl2
2: Heating
3: 84 percent / LiBH4
4: 72 percent / TsOH
5: LDA
6: aq. H2O2
7: OsO4; NMO
8: TsOH / acetone
9: 73 percent / NH2NH2; 10 percent Pd/C / methanol / Heating
10: NaH / tetrahydrofuran; dimethylformamide
11: H2 / Pd(OH)2 / ethanol / 2585.74 Torr
12: 97 percent / NaH / tetrahydrofuran; dimethylformamide
13: 24 percent / aq. cerium(IV) ammonium nitrate / acetonitrile
With
palladium on activated charcoal; osmium(VIII) oxide; lithium borohydride; thionyl chloride; N-methyl-2-indolinone; ammonium cerium(IV) nitrate; hydrogen; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; hydrazine; lithium diisopropyl amide;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetone; acetonitrile;
1: Chlorination / 2: Cyclization / 3: Reduction / 4: Cyclization / 5: Metallation / 5: selenylation / 6: oxidative olefination / 7: Oxidation / 8: transacetalization / 9: Ring cleavage / 10: protection / 11: Hydrogenolysis / 12: Methylation / 13: deprotection;
DOI:10.1021/ja992135e
![(3aR,6R,6aR)-5-(4-Methoxy-benzyl)-6-methoxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-one](/Databaselist/images/loading.webp)
