5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole

Base Information

Chemical Name:5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole
CAS No.:1366767-74-9
Molecular Formula:C₁₆H₁₈BrN₅O
Molecular Weight:376.256
Hs Code.:

Synonyms:5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole

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Chemical Property of 5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole

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Technology Process of 5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole

There total 8 articles about 5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (3R)-3-{[5-(4-bromophenyl)-1H-tetrazol-1-yl]methyl}-1-pyrrolidinecarboxylic acid hydrochloride

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1366767-74-9
5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole

Guidance literature:: (3R)-3-{[5-(4-bromophenyl)-1H-tetrazol-1-yl]methyl}-1-pyrrolidinecarboxylic acid hydrochloride; cyclopropanecarboxylic acid chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 586-76-5
4-Bromobenzoic acid

: 1366767-74-9
5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 25 °C

1.2: 20 °C / Cooling with ice

2.1: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 25 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 25 °C

With hydrogenchloride; oxalyl dichloride; trimethylsilylazide; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1366767-74-9
5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 25 °C

1.2: 20 °C / Cooling with ice

2.1: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 25 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 25 °C

With hydrogenchloride; oxalyl dichloride; trimethylsilylazide; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;