5-[4-(1-benzofuran-5-yl)phenyl]-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazol

Base Information

Chemical Name:5-[4-(1-benzofuran-5-yl)phenyl]-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazol
CAS No.:1366766-53-1
Molecular Formula:C₂₄H₂₃N₅O₂
Molecular Weight:413.479
Hs Code.:

Synonyms:5-[4-(1-benzofuran-5-yl)phenyl]-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazol

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Chemical Property of 5-[4-(1-benzofuran-5-yl)phenyl]-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazol

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Technology Process of 5-[4-(1-benzofuran-5-yl)phenyl]-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazol

There total 9 articles about 5-[4-(1-benzofuran-5-yl)phenyl]-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 519054-55-8
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran

: 1366767-74-9
5-(4-bromophenyl)-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazole

: 1366766-53-1
5-[4-(1-benzofuran-5-yl)phenyl]-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazol

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; acetonitrile; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 586-76-5
4-Bromobenzoic acid

: 1366766-53-1
5-[4-(1-benzofuran-5-yl)phenyl]-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazol

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 25 °C

1.2: 20 °C / Cooling with ice

2.1: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 25 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 25 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 2 h / 90 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; trimethylsilylazide; di-isopropyl azodicarboxylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1366766-53-1
5-[4-(1-benzofuran-5-yl)phenyl]-1-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-1H-tetrazol

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 25 °C

1.2: 20 °C / Cooling with ice

2.1: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 25 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 25 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 2 h / 90 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; trimethylsilylazide; di-isopropyl azodicarboxylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;