4-[(5-(isoquinolin-5-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile

Base Information

Chemical Name:4-[(5-(isoquinolin-5-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile
CAS No.:237751-17-6
Molecular Formula:C₂₅H₁₉N₅O₂S
Molecular Weight:453.524
Hs Code.:

Synonyms:4-[(5-(isoquinolin-5-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile

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Chemical Property of 4-[(5-(isoquinolin-5-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile

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Technology Process of 4-[(5-(isoquinolin-5-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile

There total 5 articles about 4-[(5-(isoquinolin-5-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5462-71-5
4-cyanophenylacetic acid

: 237751-17-6
4-[(5-(isoquinolin-5-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: CDI / tetrahydrofuran / 0.5 h / 50 °C

1.2: 79 percent / tetrahydrofuran / 2 h / 50 °C

2.1: 93 percent / glacial acetic acid / 1 h / Heating

3.1: 100 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂

4.1: pyridine / 20 °C

With pyridine; hydrogen; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0109513

Reference yield:

: 41939-61-1
N₁-methyl-4-nitrobenzene-1,2-diamine

: 237751-17-6
4-[(5-(isoquinolin-5-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: CDI / tetrahydrofuran / 0.5 h / 50 °C

1.2: 79 percent / tetrahydrofuran / 2 h / 50 °C

2.1: 93 percent / glacial acetic acid / 1 h / Heating

3.1: 100 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂

4.1: pyridine / 20 °C

With pyridine; hydrogen; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0109513

Reference yield:

: 236417-27-9
4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile

: 237751-17-6
4-[(5-(isoquinolin-5-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂

2: pyridine / 20 °C

With pyridine; hydrogen; 10percent Pd/C; In methanol; dichloromethane;
DOI:10.1021/jm0109513