4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile

Base Information

• Chemical Name: 4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile
• CAS No.: 236417-27-9
• Molecular Formula: C₁₆H₁₂N₄O₂
• Molecular Weight: 292.297
• Mol file: 236417-27-9.mol

Synonyms:4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile

Chemical Property of 4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile

There total 2 articles about 4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide (850464-49-2) → 4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile (236417-27-9)

Guidance literature:

With acetic acid; for 1h; Heating;

DOI:10.1021/jm0109513

Reference yield:

4-cyanophenylacetic acid (5462-71-5) → 4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile (236417-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CDI / tetrahydrofuran / 0.5 h / 50 °C

1.2: 79 percent / tetrahydrofuran / 2 h / 50 °C

2.1: 93 percent / glacial acetic acid / 1 h / Heating

With acetic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran;

DOI:10.1021/jm0109513

Reference yield: 100.0%

4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile (236417-27-9) → 4-(5-amino-1-methyl-1H-benzoimidazol-2-ylmethyl)benzonitrile (236417-28-0)

Guidance literature:

With hydrogen; 10percent Pd/C; In methanol; dichloromethane;

DOI:10.1021/jm0109513

upstream raw materials:

2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide

4-cyanophenylacetic acid

Downstream raw materials:

4-(5-amino-1-methyl-1H-benzoimidazol-2-ylmethyl)benzonitrile

N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide

4-[(5-(pyridin-3-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile

N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]benzenesulfonamide