(2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

Base Information

Chemical Name:(2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester
CAS No.:623158-09-8
Molecular Formula:C₂₄H₃₀N₂O₄
Molecular Weight:410.513
Hs Code.:

Synonyms:(2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

Suppliers and Price of (2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

There total 2 articles about (2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 133038-44-5
[(benzylidene)amino]acetic acid ethyl ester

: 623157-95-9
N-((1R,2S)-2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-acrylamide

: 623158-09-8
(2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

Guidance literature:: With silver(I) acetate; triethylamine; In toluene; at 20 ℃; for 24h;
DOI:10.1055/s-2003-39325

Reference yield:

: 24221-86-1
(+)-(1S,2R)-ephedrine hydrochloride

: 623158-09-8
(2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 20 °C

2: 76 percent / triethylamine; AgOAc / toluene / 24 h / 20 °C

With silver(I) acetate; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.tet.2005.02.009

Reference yield: 91.0%

: 100-39-0
benzyl bromide

: 623158-09-8
(2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

: (2S,3R)-5-(Hydroxy-diphenyl-methyl)-2-phenyl-pyrrolidine-3-carboxylic acid ((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: benzyl bromide; With magnesium; In diethyl ether; at 20 ℃; for 1h;

(2R,4R,5S)-4-[((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-5-phenyl-pyrrolidine-2-carboxylic acid ethyl ester; In diethyl ether; for 2h; Heating;
DOI:10.1016/j.tet.2005.02.009