(2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate

Base Information

Chemical Name:(2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate
CAS No.:1192873-15-6
Molecular Formula:C₁₈H₂₃BN₄OS
Molecular Weight:354.284
Hs Code.:

Synonyms:(2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate

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Chemical Property of (2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate

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Technology Process of (2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate

There total 3 articles about (2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1192873-13-4
(3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate

: 1192873-15-6
(2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate

Guidance literature:: With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

Reference yield:

: 1192811-95-2
N-(5-phenylthiazol-2-yl)-1H-imidazole-1-carbothioamide

: 1192873-15-6
(2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 15 h / 65 °C

2: diisopropyl-carbodiimide / N,N-dimethyl-formamide / 4 h / 70 °C

With diisopropyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b01506

Reference yield:

: 39136-63-5
5-phenyl-1,3-thiazol-2-amine

: 1192873-15-6
(2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 24 h / 50 °C

2: N,N-dimethyl-formamide / 15 h / 65 °C

3: diisopropyl-carbodiimide / N,N-dimethyl-formamide / 4 h / 70 °C

With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01506