(3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate

Base Information

• Chemical Name: (3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate
• CAS No.: 1192873-13-4
• Molecular Formula: C₁₈H₂₅BN₄OS₂
• Molecular Weight: 388.366
• Mol file: 1192873-13-4.mol

Synonyms:(3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate

Chemical Property of (3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate

There total 2 articles about (3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.4%

N-(5-phenylthiazol-2-yl)-1H-imidazole-1-carbothioamide (1192811-95-2) + (3-(aminomethyl)-3-hydroxy-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate (128653-87-2) → (3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate (1192873-13-4)

Guidance literature:

In N,N-dimethyl-formamide; at 65 ℃; for 5h;

Reference yield:

5-phenyl-1,3-thiazol-2-amine (39136-63-5) → (3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate (1192873-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 2 h / 65 °C

2: N,N-dimethyl-formamide / 5 h / 65 °C

In N,N-dimethyl-formamide; acetonitrile;

Reference yield: 70.0%

(3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate (1192873-13-4) → (2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate (1192873-15-6)

Guidance literature:

With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

upstream raw materials:

N-(5-phenylthiazol-2-yl)-1H-imidazole-1-carbothioamide

(3-(aminomethyl)-3-hydroxy-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate

5-phenyl-1,3-thiazol-2-amine

Downstream raw materials:

(2-(5-phenylthiazol-2-ylamino)-4H-1'-ammoniospiro-[oxazole-5,3'-bicyclo[2.2.2]octane]-1'-yl)trihydroborate

N-(5-phenylthiazol-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

(R)-N-(5-phenylthiazol-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

(S)-N-(5-phenylthiazol-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine