{1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester

Base Information

Chemical Name:{1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester
CAS No.:1000611-85-7
Molecular Formula:C₂₄H₂₈N₄O₃S
Molecular Weight:452.577
Hs Code.:

Synonyms:{1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester

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Chemical Property of {1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester

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Technology Process of {1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester

There total 5 articles about {1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1000611-84-6
methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate

: 1000611-85-7
{1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 40h; under 2068.65 Torr; Product distribution / selectivity;

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 1000611-85-7
{1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogen bromide / water; tetrahydrofuran / 1.5 h / 0 °C

3.1: acetonitrile / 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 40 h / 2068.65 Torr / Parr hydrogenation apparatus

With hydrogen bromide; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 127106-74-5
(S)-[3-diazo-1-(4-nitrobenzyl)-2-oxo-propyl]carbamic acid tert-butyl ester

: 1000611-85-7
{1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide / water; tetrahydrofuran / 1.5 h / 0 °C

2: acetonitrile / 2 h / Reflux

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 40 h / 2068.65 Torr / Parr hydrogenation apparatus

With hydrogen bromide; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;