4-((S)-2-((S)-2-(methoxycarbonylamino)-3-phenylpropanamido)-2-(2-ethylthiazol-4-yl) ethyl)phenylsulfamic acid

Base Information

Chemical Name:4-((S)-2-((S)-2-(methoxycarbonylamino)-3-phenylpropanamido)-2-(2-ethylthiazol-4-yl) ethyl)phenylsulfamic acid
CAS No.:1000611-24-4
Molecular Formula:C₂₄H₂₈N₄O₆S₂
Molecular Weight:532.642
Hs Code.:

Synonyms:4-((S)-2-((S)-2-(methoxycarbonylamino)-3-phenylpropanamido)-2-(2-ethylthiazol-4-yl) ethyl)phenylsulfamic acid

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Chemical Property of 4-((S)-2-((S)-2-(methoxycarbonylamino)-3-phenylpropanamido)-2-(2-ethylthiazol-4-yl) ethyl)phenylsulfamic acid

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Technology Process of 4-((S)-2-((S)-2-(methoxycarbonylamino)-3-phenylpropanamido)-2-(2-ethylthiazol-4-yl) ethyl)phenylsulfamic acid

There total 6 articles about 4-((S)-2-((S)-2-(methoxycarbonylamino)-3-phenylpropanamido)-2-(2-ethylthiazol-4-yl) ethyl)phenylsulfamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1000611-85-7
{1-[2-(S)-(4-(1S)-aminophenyl)-1-(2-ethylthiazol-4-yl)ethylcarbamoyl]-2-phenylethyl}carbamic acid methyl ester

: 1000611-24-4
4-((S)-2-((S)-2-(methoxycarbonylamino)-3-phenylpropanamido)-2-(2-ethylthiazol-4-yl) ethyl)phenylsulfamic acid

Guidance literature:: With pyridine-SO₃ complex; In acetonitrile; at 20 - 39 ℃; for 0.75h;

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 1000611-24-4
4-((S)-2-((S)-2-(methoxycarbonylamino)-3-phenylpropanamido)-2-(2-ethylthiazol-4-yl) ethyl)phenylsulfamic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogen bromide / water; tetrahydrofuran / 1.5 h / 0 °C

3.1: acetonitrile / 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 40 h / 2068.65 Torr / Parr hydrogenation apparatus

6.1: sulfur trioxide pyridine complex / acetonitrile / 0.75 h / 20 - 39 °C

6.2: 20 °C / pH 1.4

With hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1000611-84-6
methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate

: 1000611-24-4
4-((S)-2-((S)-2-(methoxycarbonylamino)-3-phenylpropanamido)-2-(2-ethylthiazol-4-yl) ethyl)phenylsulfamic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 40 h / 2068.65 Torr / Parr hydrogenation apparatus

2.1: sulfur trioxide pyridine complex / acetonitrile / 0.75 h / 20 - 39 °C

2.2: 20 °C / pH 1.4

With hydrogen; sulfur trioxide pyridine complex; palladium 10% on activated carbon; In methanol; acetonitrile;