methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate

Base Information

Chemical Name:methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate
CAS No.:1000611-84-6
Molecular Formula:C₂₄H₂₆N₄O₅S
Molecular Weight:482.56
Hs Code.:

Synonyms:methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate

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Chemical Property of methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate

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Technology Process of methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate

There total 5 articles about methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1235331-98-2
1-(S)-(4-ethylthiazol-2-yl)-2-(2-nitrophenyl)ethylamine hydrobromide

: 41844-91-1
N-methoxycarbonyl-L-phenylalanine

: 1000611-84-6
methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield: 81.0%

: 1235331-98-2
1-(S)-(4-ethylthiazol-2-yl)-2-(2-nitrophenyl)ethylamine hydrobromide

: 19887-32-2
(ethoxycarbonyl)-L-phenylalanine

: 1000611-84-6
methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 1000611-84-6
methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogen bromide / water; tetrahydrofuran / 1.5 h / 0 °C

3.1: acetonitrile / 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogen bromide; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;