N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine

Base Information

Chemical Name:N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
CAS No.:1059172-55-2
Molecular Formula:C₁₈H₁₄ClFN₆
Molecular Weight:368.801
Hs Code.:

Synonyms:N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine

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Chemical Property of N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine

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Technology Process of N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine

There total 9 articles about N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 404827-81-2
4-chloro-2-(2-chloro-phenyl)-5,6-dimethyl-pyrimidine

: 1034667-22-5
5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-amine

: 1059172-55-2
N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine

Guidance literature:: 4-chloro-2-(2-chloro-phenyl)-5,6-dimethyl-pyrimidine; 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-amine; In 1-methyl-pyrrolidin-2-one; at 135 ℃; for 3.5h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 1059172-55-2
N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; formic acid / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C

4.1: hydrazine hydrate / butan-1-ol / 4 h / Reflux

5.1: 1-methyl-pyrrolidin-2-one / 3.5 h / 135 °C

With formic acid; oxalyl dichloride; hydrazine hydrate; triethylamine; trifluoroacetic anhydride; palladium diacetate; N,N-dimethyl-formamide; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 38186-88-8
2-chloro-5-fluoronicotinic acid

: 1059172-55-2
N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C

3.1: hydrazine hydrate / butan-1-ol / 4 h / Reflux

4.1: 1-methyl-pyrrolidin-2-one / 3.5 h / 135 °C

With oxalyl dichloride; hydrazine hydrate; triethylamine; trifluoroacetic anhydride; N,N-dimethyl-formamide; In 1-methyl-pyrrolidin-2-one; dichloromethane; butan-1-ol;