Technology Process of N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
There total 9 articles about N-(2-(2-chlorophenyl)-5,6-dimethylpyrimidin-4-yl)-5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-chloro-2-(2-chloro-phenyl)-5,6-dimethyl-pyrimidine; 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-amine;
In
1-methyl-pyrrolidin-2-one;
at 135 ℃;
for 3.5h;
With
sodium hydrogencarbonate;
In
water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; formic acid / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
2.2: 0 - 20 °C
3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C
4.1: hydrazine hydrate / butan-1-ol / 4 h / Reflux
5.1: 1-methyl-pyrrolidin-2-one / 3.5 h / 135 °C
With
formic acid; oxalyl dichloride; hydrazine hydrate; triethylamine; trifluoroacetic anhydride;
palladium diacetate; N,N-dimethyl-formamide; triphenylphosphine;
In
1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
1.2: 0 - 20 °C
2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C
3.1: hydrazine hydrate / butan-1-ol / 4 h / Reflux
4.1: 1-methyl-pyrrolidin-2-one / 3.5 h / 135 °C
With
oxalyl dichloride; hydrazine hydrate; triethylamine; trifluoroacetic anhydride;
N,N-dimethyl-formamide;
In
1-methyl-pyrrolidin-2-one; dichloromethane; butan-1-ol;