2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester

Base Information

Chemical Name:2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester
CAS No.:168702-59-8
Molecular Formula:C₃₁H₂₈N₂O₅
Molecular Weight:508.574
Hs Code.:

Synonyms:2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester

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Chemical Property of 2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester

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Technology Process of 2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester

There total 5 articles about 2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 69555-14-2
ethyl N-diphenylmethylene glycine

: 168702-55-4
5-(Benzyloxy)-2-nitrobenzyl iodide

: 168702-59-8
2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane;
DOI:10.1021/jo00108a023

Reference yield:

: 68423-36-9
(5-(benzyloxy)-2-nitrophenyl)methanol

: 168702-59-8
2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 1 h / 0 °C

2: NaI / acetone / 2 h / Ambient temperature

3: 95 percent / 10percent aq. NaOH, tetrabutylammonium hydrogen sulfate / CH₂Cl₂

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jo00108a023

Reference yield:

: 60463-12-9
3-hydroxymethyl-4-nitrophenol

: 168702-59-8
2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / NaH / tetrahydrofuran; dimethylformamide / 1.) 30-40 deg C, 30 min, 2.) r.t., 2 h

2: Et₃N / tetrahydrofuran / 1 h / 0 °C

3: NaI / acetone / 2 h / Ambient temperature

4: 95 percent / 10percent aq. NaOH, tetrabutylammonium hydrogen sulfate / CH₂Cl₂

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00108a023