68423-36-9

Upstream product

• 60463-12-9 3-hydroxymethyl-4-nitrophenol 
• 100-39-0 benzyl bromide 
• 58662-54-7 5-benzyloxy-2-nitrobenzaldehyde 
• 1826-67-1 vinyl magnesium bromide 
• 59342-81-3 ethyl (3-formyl-4-nitrophenyl) carbonate 
• 68423-35-8 ethyl (3-formylphenyl) carbonate 
• 100-51-6 benzyl alcohol 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 

Downstream Products

• 68423-37-0 2-Nitro-5-(benzyloxy)-benzylchlorid 
• 670274-94-9 4-(5-benzyloxy-2-nitro-benzyloxy)-3-ethoxy-benzaldehyde 
• 670274-98-3 4-(5-benzyloxy-2-nitro-benzyloxy)-3,5-dimethoxy-benzaldehyde 
• 1613722-69-2 10-(benzyloxy)-5,6-dihydro-8H-isoquinolino[1,2-b]quinazolin-8-one 
• 1026701-14-3 (S)-2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-propan-1-one 
• 1027080-01-8 (S)-2-[(S)-3-(5-Benzyloxy-2-nitro-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-propionic acid methyl ester 
• 168702-65-6 Fmoc-m-Nip(Bn) 
• 168702-59-8 2-(Benzhydrylidene-amino)-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid ethyl ester 
• 168702-67-8 Ac-L-m-Nip(Bn)-Ala-OMe 
• 168702-61-2 Boc-m-Nip(Bn)-OEt 
• 1027902-01-7 (S)-2-[(S)-2-Amino-3-(5-benzyloxy-2-nitro-phenyl)-propionylamino]-propionic acid methyl ester 
• 168702-63-4 Boc-L-m-Nip(Bn) 
• 1028260-79-8 (S)-2-[(S)-2-Acetylamino-3-(2-amino-5-hydroxy-phenyl)-propionylamino]-propionic acid methyl ester 
• 1026739-22-9 (S)-2-Amino-3-(5-benzyloxy-2-nitro-phenyl)-propionic acid 

Relevant academic research and scientific papers

NEW MACROCYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound of formula (I) : wherein Z, Y1,Y2,(Formula II)R1 to R7 are as defined in the description, its optical isomers, and addition salts thereof with a pharmaceutically acceptable base. Medicaments.

Synthesis of Ether Oligomers

(Equation presented) Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS

The present invention is to prepare efficiently 2'-amino-5'-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.

Design of New Photoactivatable Amino Acids: Stereoselective Synthesis of N-Protected Phenylalanine Derivatives as Precursors of p-Diazocyclohexadienone-Containing Peptides

4-Diazocyclohexa-2,5-dienone-based amino acids m-Dip and o-Dip were designed for building up photoactivatable peptides.Their stable precursors L-3-alanine (L-m-Nip(Bn)) and L-3-alanine (L-o-Nip(Bn)