1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethoxy)pyridin-3-yl)urea

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Chemical Name:1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethoxy)pyridin-3-yl)urea
CAS No.:1419600-96-6
Molecular Formula:C₁₉H₁₇ClF₃N₅O₃
Molecular Weight:455.824
Hs Code.:

Synonyms:1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethoxy)pyridin-3-yl)urea

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Chemical Property of 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethoxy)pyridin-3-yl)urea

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Technology Process of 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethoxy)pyridin-3-yl)urea

There total 10 articles about 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethoxy)pyridin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1254713-79-5
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

: 1419604-17-3
phenyl 6-(2-hydroxyethoxy)pyridin-3-ylcarbamate

: 1419600-96-6
1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethoxy)pyridin-3-yl)urea

Guidance literature:: With triethylamine; In acetonitrile; for 16h; Reflux;

Reference yield:

: 108-42-9
3-chloro-aniline

: 1419600-96-6
1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethoxy)pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water / 0.17 h / -5 - 0 °C

1.2: 5 h / -5 - 0 °C

2.1: ethanol / 3 h / Reflux

3.1: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C

4.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

5.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

6.1: triethylamine / acetonitrile / 16 h / Reflux

With hydrogenchloride; ammonia; hydrogen; triethylamine; potassium iodide; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetonitrile;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1419600-96-6
1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethoxy)pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 3 h / Reflux

2: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C

3: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

4: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

5: triethylamine / acetonitrile / 16 h / Reflux

With ammonia; hydrogen; triethylamine; potassium iodide; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; acetonitrile;