N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide
CAS No.:1421917-37-4
Molecular Formula:C₁₆H₁₁F₃N₄O
Molecular Weight:332.285
Hs Code.:

Synonyms:N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

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Chemical Property of N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

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Technology Process of N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

There total 5 articles about N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.5%

: 504-29-0
2-aminopyridine

: 1003579-29-0
1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride

: 1421917-37-4
N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 10 - 20 ℃;
DOI:10.3390/molecules171214205

Reference yield:

: 155377-19-8
ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate

: 1421917-37-4
N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: copper diacetate; pyridine / N,N-dimethyl-formamide / 24 h / 20 °C

2: lithium hydroxide / tetrahydrofuran / 2 h / 70 °C / pH 5

3: thionyl chloride / 8 h / Reflux

4: sodium hydride / tetrahydrofuran / 10 - 20 °C

With pyridine; thionyl chloride; copper diacetate; sodium hydride; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.3390/molecules171214205

Reference yield:

: 571-55-1
ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

: 1421917-37-4
N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / methanol / 3 h / 80 °C

2: copper diacetate; pyridine / N,N-dimethyl-formamide / 24 h / 20 °C

3: lithium hydroxide / tetrahydrofuran / 2 h / 70 °C / pH 5

4: thionyl chloride / 8 h / Reflux

5: sodium hydride / tetrahydrofuran / 10 - 20 °C

With pyridine; thionyl chloride; copper diacetate; sodium hydride; hydrazine hydrate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules171214205