1-Phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-Phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS No.: 741717-63-5
• Molecular Formula: C13H11 F3 N2 O2
• Molecular Weight: 284.238
• Hs Code.: 29331990
• Mol file: 741717-63-5.mol

Synonyms:1-Phenyl-3-trifluoromethyl-1H-pyrazole-4-carboxylicacid ethyl ester; Ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Chemical Property of 1-Phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester

Chemical Property:

• PSA: 44.12000
• LogP: 3.06780
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl1-Phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester

There total 7 articles about 1-Phenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

phenylboronic acid (98-80-6) + ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate (155377-19-8) → ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (741717-63-5)

Guidance literature:

With pyridine; copper diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.3390/molecules171214205

Reference yield: 85.0%

iodobenzene (591-50-4) + ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate (155377-19-8) → ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (741717-63-5)

Guidance literature:

With trans-N,N'-dimethyl-1,2-cyclohexanediamine; copper(l) iodide; potassium carbonate; In toluene; at 110 ℃; for 24h;

Reference yield: 80.0%

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate (571-55-1) + methyl N'-phenylhydrazinoformate (2290-03-1) → ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (741717-63-5)

Guidance literature:

In 1,2-dichloro-ethane; at 80 ℃; regioselective reaction;

upstream raw materials:

iodobenzene

ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate

phenylboronic acid

ethyl 4,4,4-trifluoroacetoacetate

Downstream raw materials:

(1-phenyl-3-trifluoromethyl-1H-pyrazol-4-yl)methanol

1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

N-(pyridin-4-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

N-(2-chloropyridin-4-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

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