2-bromo-3-fluorobenzoic acid ethyl ester

Base Information

• Chemical Name: 2-bromo-3-fluorobenzoic acid ethyl ester
• CAS No.: 1131040-49-7
• Molecular Formula: C₉H₈BrFO₂
• Molecular Weight: 247.064

Synonyms:2-bromo-3-fluorobenzoic acid ethyl ester

Chemical Property of 2-bromo-3-fluorobenzoic acid ethyl ester

Chemical Property:

Purity/Quality:

99%+ ^*data from raw suppliers

Ethyl2-Bromo-3-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-3-fluorobenzoic acid ethyl ester

There total 2 articles about 2-bromo-3-fluorobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

ethanol (64-17-5) + 2-bromo-3-fluoro-benzoic acid (132715-69-6) → 2-bromo-3-fluorobenzoic acid ethyl ester (1131040-49-7)

Guidance literature:

With thionyl chloride; at 85 ℃; for 3h;

Reference yield: 74.0%

ethyl 3-fluorobenzoate (451-02-5) → 2-bromo-3-fluorobenzoic acid ethyl ester (1131040-49-7)

Guidance literature:

ethyl 3-fluorobenzoate; With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; zinc(II) chloride; In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere;

With 1,2-dibromo-1,1,2,2-tetrachloroethane; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.200801558

Reference yield:

2-bromo-3-fluorobenzoic acid ethyl ester (1131040-49-7) + bis(pinacol)diborane (73183-34-3) → ethyl 3-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; In toluene; at 115 ℃; Inert atmosphere;

upstream raw materials:

ethyl 3-fluorobenzoate

ethanol

2-bromo-3-fluoro-benzoic acid

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