5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde

Base Information

• Chemical Name: 5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde
• CAS No.: 1313891-09-6
• Molecular Formula: C₁₃H₁₅BrO₄
• Molecular Weight: 315.164
• Mol file: 1313891-09-6.mol

Synonyms:5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde

Chemical Property of 5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde

There total 3 articles about 5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-bromo-2-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde (1313891-05-2) + methyl iodide (74-88-4) → 5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde (1313891-09-6)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 10h;

DOI:10.1016/j.bmcl.2011.04.057

Reference yield:

5-bromo-2,4-dihydroxy-benzaldehyde (116096-90-3) → 5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde (1313891-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 °C

2: potassium carbonate / acetone / 10 h / 20 °C

With pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2011.04.057

Reference yield:

2,4-Dihydroxybenzaldehyde (95-01-2) → 5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde (1313891-09-6)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / acetic acid / 3 h / 20 °C

2: pyridinium p-toluenesulfonate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 °C

3: potassium carbonate / acetone / 10 h / 20 °C

With bromine; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; In dichloromethane; acetic acid; acetone;

DOI:10.1016/j.bmcl.2011.04.057

upstream raw materials:

5-bromo-2-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde

methyl iodide

5-bromo-2,4-dihydroxy-benzaldehyde

2,4-Dihydroxybenzaldehyde

Downstream raw materials:

ethyl (E)-2-(4-(3-(5-bromo-4-hydroxy-2-methoxyphenyl)acryloyl)phenoxy)acetate

ethyl (E)-4-(4-(3-(5-bromo-4-hydroxy-2-methoxyphenyl)acryloyl)phenoxy)butanoate

(E)-2-(4-(3-(5-bromo-4-hydroxy-2-methoxyphenyl)acryloyl)phenoxy)acetic acid

(E)-4-(4-(3-(5-bromo-4-hydroxy-2-methoxyphenyl)acryloyl)phenoxy)butanoic acid