Synonyms:NCIOpen2_007510;CBDivE_002856;DTXSID301238756;2,3-Bis(2-phenylhydrazinylidene)butanedioic acid;89-06-5
There total 4 articles about 2,3-Bis(2-phenylhydrazinylidene)butanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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The research focuses on the synthesis of novel heterocyclic compounds, specifically 1,2,4-triazol-3-ylmethyl-, 1,3,4-oxa-, and -thiadiazol-2-ylmethyl-1H-[1,2,3]-triazolo[4,5-d]pyrimidinediones, which are potentially useful as antiviral agents against hepatitis B virus. The experiments involved the synthesis of 1-carbethoxymethyl-4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione and its subsequent reactions with hydrazine hydrate to yield a hydrazide. This hydrazide was further reacted with phenylisothiocyanate or carbon disulfide and KOH to produce thiosemicarbazide and oxadiazole derivatives. Various alkylation and cyclization reactions were performed to form the desired heterocyclic structures, including the formation of 1,3,4-thiadiazole, 5-mercapto-1,2,4-triazole, and 1,3,4-oxadiazole rings. The synthesized compounds were analyzed using techniques such as infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry (MS) to confirm their structures. The reactants used in these syntheses included phenylisothiocyanate, carbon disulfide, alcoholic potassium hydroxide, dimethyl sulfate, ethyl chloroacetate, and various monosaccharide aldoses. The synthesized compounds were tested for their antiviral activity, with some showing moderate activities against hepatitis B virus.
The research focuses on the synthesis and structural aspects of (2,5)-1,3,4-thiadiazolo and (3,5)-1,3,4-thiadiazolino thia crown ethers. The study describes a general route to synthesize (2,5)-1,3,4-thiadiazolo thia crown ethers by reacting 2,5-dimercapto-1,3,4-thiadiazole dipotassium salt with oligoethylene glycol dihalides in ethanol under high-dilution conditions. The structures of the macrocycles were confirmed by 1H and 13C NMR spectroscopy, and one of the macrocycles was further characterized by single-crystal X-ray diffraction. The research also involves the synthesis of related open-chain models for further studies on the complexing behavior and chemical reactivity of 1,3,4-thiadiazole acyclic versus cyclic structures.
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