5-amino-4-[3,5-bis(tert-butyldimethylsilanyloxymethyl)anilino]-6-chloropyrimidine

Base Information

Chemical Name:5-amino-4-[3,5-bis(tert-butyldimethylsilanyloxymethyl)anilino]-6-chloropyrimidine
CAS No.:867259-34-5
Molecular Formula:C₂₄H₄₁ClN₄O₂Si₂
Molecular Weight:509.239
Hs Code.:

Synonyms:5-amino-4-[3,5-bis(tert-butyldimethylsilanyloxymethyl)anilino]-6-chloropyrimidine

Suppliers and Price of 5-amino-4-[3,5-bis(tert-butyldimethylsilanyloxymethyl)anilino]-6-chloropyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-amino-4-[3,5-bis(tert-butyldimethylsilanyloxymethyl)anilino]-6-chloropyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-amino-4-[3,5-bis(tert-butyldimethylsilanyloxymethyl)anilino]-6-chloropyrimidine

There total 2 articles about 5-amino-4-[3,5-bis(tert-butyldimethylsilanyloxymethyl)anilino]-6-chloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 867259-33-4
5-amino-4-[3,5-bis(hydroxymethyl)anilino]-6-chloropyrimidine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 867259-34-5
5-amino-4-[3,5-bis(tert-butyldimethylsilanyloxymethyl)anilino]-6-chloropyrimidine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jo050635m

Reference yield:

: 71176-54-0
(3-amino-5-hydroxymethylphenyl)methanol

: 867259-34-5
5-amino-4-[3,5-bis(tert-butyldimethylsilanyloxymethyl)anilino]-6-chloropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / aq. HCl / ethanol / 7 h / Heating

2: 70 percent / imidazole / dimethylformamide / 24 h / 20 °C

With 1H-imidazole; hydrogenchloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo050635m