6-phenyl-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

Base Information

Chemical Name:6-phenyl-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine
CAS No.:1415380-82-3
Molecular Formula:C₂₂H₂₂N₆
Molecular Weight:370.457
Hs Code.:

Synonyms:6-phenyl-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

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Chemical Property of 6-phenyl-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

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Technology Process of 6-phenyl-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

There total 6 articles about 6-phenyl-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415314-17-8
6-chloro-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

: 98-80-6
phenylboronic acid

: 1415380-82-3
6-phenyl-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos; In 1,4-dioxane; water; at 100 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm301367c

Reference yield:

: 1597-32-6
6-fluoro-pyridin-2-ylamine

: 1415380-82-3
6-phenyl-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

Guidance literature:: Multi-step reaction with 3 steps

1: water / 0.5 h / 205 °C / Microwave irradiation

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 16 h / 20 °C / Inert atmosphere

3: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 3: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm301367c

Reference yield:

: 110-89-4
piperidine

: 1415380-82-3
6-phenyl-N-(6-(piperidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

Guidance literature:: Multi-step reaction with 3 steps

1: water / 0.5 h / 205 °C / Microwave irradiation

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 16 h / 20 °C / Inert atmosphere

3: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 3: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm301367c