(E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester

Base Information

• Chemical Name: (E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester
• CAS No.: 85960-30-1
• Molecular Formula: C₁₆H₁₇NO₄S
• Molecular Weight: 319.381

Synonyms:(E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester

Chemical Property of (E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester

Chemical Property:

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Technology Process of (E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester

There total 2 articles about (E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzenesulfonyl chloride (98-09-9) + ethyl (E)-3-(4-methyl-1H-pyrrol-3-yl)acrylate (85960-29-8) → (E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester (85960-30-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1039/c39830000026

Reference yield:

(2E,4E)-ethyl hexa-2,4-dienoate (2396-84-1) → (E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester (85960-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaH / dimethylsulfoxide; diethyl ether / 3 h / 20 °C

2: 90 percent / NaH / tetrahydrofuran

With sodium hydride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;

DOI:10.1039/c39830000026

Reference yield: 96.0%

α-allyl-(tosylmethyl) isocyanide (58379-85-4) + (E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester (85960-30-1) → 2-Allyl-1'-benzenesulfonyl-4'-methyl-1H,1'H-[3,3']bipyrrolyl-4-carboxylic acid ethyl ester (85960-32-3)

Guidance literature:

With sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran;

DOI:10.1021/ja00243a025

upstream raw materials:

benzenesulfonyl chloride

ethyl (E)-3-(4-methyl-1H-pyrrol-3-yl)acrylate

(2E,4E)-ethyl hexa-2,4-dienoate

Downstream raw materials:

ethyl 4-methyl-1-(phenylsulfonyl)-3,3'-bipyrrole-4'-carboxylate

2-Allyl-1'-benzenesulfonyl-4'-methyl-1H,1'H-[3,3']bipyrrolyl-4-carboxylic acid ethyl ester

ethyl 2'-((N,N-dimethylamino)methyl)-4-methyl-1-(phenylsulfonyl)-3,3'-bipyrrole-4'-carboxylate

ethyl 2'-(formylmethyl)-4-methyl-1-(phenylsulfonyl)-3,3'-bipyrrole-4'-carboxylate

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