1,4-anhydro-5-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pentitol 3-(diphenylphosphate)

Base Information

Chemical Name:1,4-anhydro-5-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pentitol 3-(diphenylphosphate)
CAS No.:194724-15-7
Molecular Formula:C₂₃H₃₃O₆PSi
Molecular Weight:464.571
Hs Code.:

Synonyms:1,4-anhydro-5-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pentitol 3-(diphenylphosphate)

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Chemical Property of 1,4-anhydro-5-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pentitol 3-(diphenylphosphate)

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Technology Process of 1,4-anhydro-5-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pentitol 3-(diphenylphosphate)

There total 5 articles about 1,4-anhydro-5-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pentitol 3-(diphenylphosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 194724-12-4
(2R,3S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]tetrahydrofuran-3-ol

: 194724-15-7
1,4-anhydro-5-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pentitol 3-(diphenylphosphate)

Guidance literature:: With dmap; In pyridine; for 0.5h; Ambient temperature;
DOI:10.1016/S0040-4020(97)00363-3

Reference yield:

: 91547-59-0
(2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol

: 194724-15-7
1,4-anhydro-5-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pentitol 3-(diphenylphosphate)

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / imidazole / dimethylformamide / 0.17 h / Ambient temperature

2: 92 percent / DMAP / pyridine / 0.5 h / Ambient temperature

With 1H-imidazole; dmap; In pyridine; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00363-3

Reference yield:

: 452-51-7,13046-70-3,29780-54-9,36792-87-7,36792-88-8,113890-35-0,113890-38-3
D-2-deoxyribose

: 194724-15-7
1,4-anhydro-5-O-(tert-butyldimethylsilyl)-2-deoxy-D-erythro-pentitol 3-(diphenylphosphate)

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / conc. H₂SO₄ / 24 h / 4 °C

2: 1.) BSTFA, 2.) Et₃SiH, TMSOTf / 1.) CH₃CN, 78-80 deg C, 3 h, 2.) overnight, room temperature

3: 76 percent / imidazole / dimethylformamide / 0.17 h / Ambient temperature

4: 92 percent / DMAP / pyridine / 0.5 h / Ambient temperature

With 1H-imidazole; triethylsilane; dmap; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; N,O-Bis(trimethylsilyl)trifluoroacetamide; In pyridine; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00363-3