7-fluoro-3-(4-methanesulfonyl-phenyl)-2-(4-methoxyphenyl)-3H-quinazolin-4-one

Base Information

Chemical Name:7-fluoro-3-(4-methanesulfonyl-phenyl)-2-(4-methoxyphenyl)-3H-quinazolin-4-one
CAS No.:1323873-41-1
Molecular Formula:C₂₂H₁₇FN₂O₄S
Molecular Weight:424.452
Hs Code.:

Synonyms:7-fluoro-3-(4-methanesulfonyl-phenyl)-2-(4-methoxyphenyl)-3H-quinazolin-4-one

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Chemical Property of 7-fluoro-3-(4-methanesulfonyl-phenyl)-2-(4-methoxyphenyl)-3H-quinazolin-4-one

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Technology Process of 7-fluoro-3-(4-methanesulfonyl-phenyl)-2-(4-methoxyphenyl)-3H-quinazolin-4-one

There total 4 articles about 7-fluoro-3-(4-methanesulfonyl-phenyl)-2-(4-methoxyphenyl)-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1323873-26-2
7-fluoro-2-(4-methoxy-phenyl)-3-(4-methylsulfanylphenyl)-3H-quinazolin-4-one

: 1323873-41-1
7-fluoro-3-(4-methanesulfonyl-phenyl)-2-(4-methoxyphenyl)-3H-quinazolin-4-one

Guidance literature:: With oxone; In tetrahydrofuran; methanol; water; at 25 ℃;
DOI:10.1016/j.bmc.2011.06.019

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 1323873-41-1
7-fluoro-3-(4-methanesulfonyl-phenyl)-2-(4-methoxyphenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 25 °C

2: toluene-4-sulfonic acid; acetic acid / Reflux

3: oxone / tetrahydrofuran; methanol; water / 25 °C

With pyridine; oxone; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2011.06.019

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 1323873-41-1
7-fluoro-3-(4-methanesulfonyl-phenyl)-2-(4-methoxyphenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 25 °C

2: toluene-4-sulfonic acid; acetic acid / Reflux

3: oxone / tetrahydrofuran; methanol; water / 25 °C

With pyridine; oxone; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2011.06.019