2,6-dichloro-N³-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine

Base Information

Chemical Name:2,6-dichloro-N³-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine
CAS No.:1616435-35-8
Molecular Formula:C₁₄H₂₁Cl₂N₃
Molecular Weight:302.247
Hs Code.:

2,6-dichloro-N<SUP>3</SUP>-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine

Synonyms:2,6-dichloro-N³-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine

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Chemical Property of 2,6-dichloro-N³-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine

Chemical Property:

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Technology Process of 2,6-dichloro-N³-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine

There total 9 articles about 2,6-dichloro-N³-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1616435-34-7
tert-butyl (2,6-dichloro-3-((1-((trans)-4-methylcyclohexyl)ethyl)amino)pyridin-4-yl)carbamate

: 1616435-35-8
2,6-dichloro-N³-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 50 ℃; for 12h;
DOI:10.1021/acs.jmedchem.1c01524

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616435-35-8
2,6-dichloro-N³-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 3 h / 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: toluene-4-sulfonic acid / toluene / 14 h / Dean-Stark; Reflux

4.1: acetic acid; sodium cyanoborohydride / ethanol / 4 h / 50 °C

5.1: hydrogenchloride / 1,4-dioxane / 12 h / 50 °C

With hydrogenchloride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 910910-20-2
(1r,4r)-N-methoxy-N,4-dimethylcyclohexane-1-carboxamide

: 1616435-35-8
2,6-dichloro-N³-(1-((trans)-4-methylcyclohexyl)ethyl)pyridine-3,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 - 20 °C

2: toluene-4-sulfonic acid / toluene / 14 h / Dean-Stark; Reflux

3: acetic acid; sodium cyanoborohydride / ethanol / 4 h / 50 °C

4: hydrogenchloride / 1,4-dioxane / 12 h / 50 °C

With hydrogenchloride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene;