(2-hydroxy-1,1,3,3-tetramethyl-2-indanyl)methyl 3-chlorobenzoate

Base Information

• Chemical Name: (2-hydroxy-1,1,3,3-tetramethyl-2-indanyl)methyl 3-chlorobenzoate
• CAS No.: 154866-30-5
• Molecular Formula: C₂₁H₂₃ClO₃
• Molecular Weight: 358.865
• Mol file: 154866-30-5.mol

Synonyms:(2-hydroxy-1,1,3,3-tetramethyl-2-indanyl)methyl 3-chlorobenzoate

Chemical Property of (2-hydroxy-1,1,3,3-tetramethyl-2-indanyl)methyl 3-chlorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-hydroxy-1,1,3,3-tetramethyl-2-indanyl)methyl 3-chlorobenzoate

There total 7 articles about (2-hydroxy-1,1,3,3-tetramethyl-2-indanyl)methyl 3-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(1,1,3,3-tetramethyl-2-indanylidene)methane (150799-08-9) → 1,1,3,3-tetramethylspiro (154866-27-0) + (2-hydroxy-1,1,3,3-tetramethyl-2-indanyl)methyl 3-chlorobenzoate (154866-30-5)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrachloromethane; for 1.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81904-9

Reference yield:

1,1,3,3-tetramethylindane-2-one (5689-12-3) → (2-hydroxy-1,1,3,3-tetramethyl-2-indanyl)methyl 3-chlorobenzoate (154866-30-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -55 deg C, room temp., 90 min; 2.) THF, -65 deg C, room temp.

2: 28 percent / SOCl₂ / pyridine / Ambient temperature

3: 70 percent / CHCl₃ / 16 h / 80 °C

4: potassium tert-butoxide / tetrahydrofuran / 2 h / Ambient temperature

5: NaHCO₃ / CCl₄ / 1.5 h / 2 °C

With n-butyllithium; thionyl chloride; potassium tert-butylate; sodium hydrogencarbonate; In tetrahydrofuran; pyridine; tetrachloromethane; chloroform;

DOI:10.1016/S0040-4020(01)81904-9

Reference yield:

3-chloro-benzenecarboperoxoic acid (937-14-4) + (1,1,3,3-tetramethyl-2-indanylidene)methane (150799-08-9) → 1,1,3,3-tetramethylspiro (154866-27-0) + (2-hydroxy-1,1,3,3-tetramethyl-2-indanyl)methyl 3-chlorobenzoate (154866-30-5)

Guidance literature:

With sodium hydrogencarbonate; In tetrachloromethane; at 2 ℃; for 1.5h;

DOI:10.1016/S0040-4020(01)81904-9

upstream raw materials:

3-chloro-benzenecarboperoxoic acid

(1,1,3,3-tetramethyl-2-indanylidene)methane

1,1,3,3-tetramethylindane-2-one

phenyl <(1,1,3,3-tetramethyl-2-indanylidene)methyl> thioether