tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate

Base Information

Chemical Name:tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate
CAS No.:828293-20-5
Molecular Formula:C₄₇H₇₅N₅O₈S
Molecular Weight:870.207
Hs Code.:

Synonyms:tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate

Suppliers and Price of tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate

There total 9 articles about tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32703-87-0
N-tertiarybutoxycarbonyl-β-alanine N-hydroxysuccinimide ester

: 3-Amino-N-{3-[[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]-(2-nitro-benzenesulfonyl)-amino]-propyl}-propionamide

: 828293-20-5
tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 5h;
DOI:10.1021/ja046663o

Reference yield:

: 474-77-1
epicholesterol

: 828293-20-5
tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1: 64 percent / HN₃; PPh₃; diethylazodicarboxylate / benzene; toluene / 2 h / 23 °C

2: LiAlH₄ / diethyl ether / 2 h / 4 - 23 °C

3: 3.50 g / diisopropylethylamine / tetrahydrofuran / 2 h / 23 °C

4: 78 percent / K₂CO₃ / N,N-dimethyl-acetamide / 20 h / 120 °C

5: trifluoroacetic acid / CH₂Cl₂ / 1 h / 23 °C

6: 103 mg / diisopropylethylamine / CH₂Cl₂ / 5 h / 23 °C

7: trifluoroacetic acid / CH₂Cl₂ / 1 h / 23 °C

8: 52 mg / diisopropylethylamine / CH₂Cl₂ / 5 h / 23 °C

With lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; toluene; benzene; 1: Mitsunobu reaction;
DOI:10.1021/ja046663o

Reference yield:

: 601-54-7
Cholest-5-en-3-one

: 828293-20-5
tert-butyl 3-({3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}amino)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1: 4.98 g / L-selectride / tetrahydrofuran / -78 - 23 °C

2: 64 percent / HN₃; PPh₃; diethylazodicarboxylate / benzene; toluene / 2 h / 23 °C

3: LiAlH₄ / diethyl ether / 2 h / 4 - 23 °C

4: 3.50 g / diisopropylethylamine / tetrahydrofuran / 2 h / 23 °C

5: 78 percent / K₂CO₃ / N,N-dimethyl-acetamide / 20 h / 120 °C

6: trifluoroacetic acid / CH₂Cl₂ / 1 h / 23 °C

7: 103 mg / diisopropylethylamine / CH₂Cl₂ / 5 h / 23 °C

8: trifluoroacetic acid / CH₂Cl₂ / 1 h / 23 °C

9: 52 mg / diisopropylethylamine / CH₂Cl₂ / 5 h / 23 °C

With lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; L-Selectride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; toluene; benzene; 2: Mitsunobu reaction;
DOI:10.1021/ja046663o