methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-trichloroacetoxypropanoate

Base Information

Chemical Name:methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-trichloroacetoxypropanoate
CAS No.:283602-71-1
Molecular Formula:C₁₅H₁₄Cl₅NO₅
Molecular Weight:465.545
Hs Code.:

Synonyms:methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-trichloroacetoxypropanoate

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Chemical Property of methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-trichloroacetoxypropanoate

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Technology Process of methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-trichloroacetoxypropanoate

There total 4 articles about methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-trichloroacetoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 76-02-8
trifluoroacetyl chloride

: 283602-70-0
methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-hydroxy propanoate

: 283602-71-1
methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-trichloroacetoxypropanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 144001-42-3
methyl 2-(benzylamino)-3-hydroxypropanoate

: 283602-71-1
methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-trichloroacetoxypropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Et₃N; N,N-dimethylaminopyridine / CH₂Cl₂ / 20 °C

2: 50 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: 56 percent / p-TsOH / methanol / 20 °C

4: 39 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With dmap; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; 1: silylation / 2: Condensation / 3: desilylation / 4: Condensation;

Reference yield:

: 160848-03-3
methyl (2R,S)-2-(N-benzylamino)-3-(tert-butyldimethylsiloxy)propanoate

: 283602-71-1
methyl 2-(N-benzyl-2,2-dichloroethanamido)-3-trichloroacetoxypropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: 56 percent / p-TsOH / methanol / 20 °C

3: 39 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; 1: Condensation / 2: desilylation / 3: Condensation;