144001-42-3

Basic information

• Product Name: N-Benzyl-DL-serine Methyl Ester
• Synonyms: N-Benzyl-DL-serine Methyl Ester;Methyl 2-(benzylaMino)-3-hydroxypropanoate;N-(phenylmethyl)Serine methyl ester;N-(Phenylmethyl)-DL-serine methyl ester
• CAS NO: 144001-42-3
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.2417
• Mol File: 144001-42-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 351.1±32.0 °C(Predicted)
• Appearance: /
• Density: 1.149±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 13.94±0.10(Predicted)
• CAS DataBase Reference: N-Benzyl-DL-serine Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-DL-serine Methyl Ester(144001-42-3)
• EPA Substance Registry System: N-Benzyl-DL-serine Methyl Ester(144001-42-3)

Safety Data

• Hazardous Substances Data: 144001-42-3(Hazardous Substances Data)

Usage

General Description

N-Benzyl-DL-serine Methyl Ester is a chemical compound made up of a benzyl group, a serine amino acid, and a methyl ester functional group. It is commonly used as a reagent in organic synthesis and pharmaceutical research. It is a white crystalline solid that is typically handled under inert gas conditions due to its sensitivity to air and moisture. N-Benzyl-DL-serine Methyl Ester has been investigated for its potential as a chiral building block in the synthesis of various pharmaceutical compounds and as a precursor for the production of biologically active molecules. Additionally, it has been studied for its potential role in the development of new materials and as a potential intermediate in the production of innovative chemical products.

Upstream product

• 5874-57-7 R-(-)-serine methyl ester hydrochloride 
• 100-52-7 benzaldehyde 
• 2104-89-4 D-serine methyl ester 
• 2104-89-4 Ser-OMe 
• 100-39-0 benzyl bromide 
• 5619-04-5 methyl 2-amino-3-hydroxypropanoate hydrochloride 
• 67-56-1 methanol 
• 106910-76-3 (RS)-N-benzylserine 
• 113729-05-8 3-benzyloxazolidine-4-carboxylate de methyle 
• 40216-75-9 (R)-3-Hydroxy-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester 

Downstream Products

• 199786-65-7 N-benzyl-N-carbobenzyloxy-O-tert-butyldimethylsilyl-D-serinal 
• 199786-66-8 Benzyl-[(1R,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-hydroxy-pent-4-enyl]-carbamic acid benzyl ester 
• 1008785-29-2 C₁₈H₂₀N₂O₄ 
• 1008785-33-8 1-benzyl-5-methylene-3-phenylimidazolidine-2,4-dione 
• 113729-05-8 3-benzyloxazolidine-4-carboxylate de methyle 
• 403804-62-6 methyl 2-(benzyl(methyl)amino)-3-hydroxypropanoate 
• 283602-68-6 methyl 2-(N-benzyl-2,2,2-tichloroethanamido)-3-trichloroacetoxy propanoate 
• 160848-03-3 methyl (2R,S)-2-(N-benzylamino)-3-(tert-butyldimethylsiloxy)propanoate 
• 160848-10-2 methyl 2-(N-benzyl-2,2-dichloroethanamido)propenoate 
• 155086-13-8 3-benzyl-2,2-dimethyloxazolidine-4-carboxylate de methyle 

Relevant articles and documents

Radical 1,4-Aryl Migration Enabled Remote Cross-Electrophile Coupling of α-Amino-β-Bromo Acid Esters with Aryl Bromides

We report an unprecedented, efficient nickel-catalysed radical relay for the remote cross-electrophile coupling of β-bromo-α-benzylamino acid esters with aryl bromides via 1,4-aryl migration/arylation cascades. β-Bromo-α-benzylamino acid esters are consid

Deoxyradiofluorination Reaction from β-Hydroxy-α-aminoesters: an Entry to [18F]Fluoroaminoesters under Mild Conditions

We report the conversion of β-hydroxy-α-aminoesters derived from serine, α-methylserine or β-phenylserine to the corresponding [18F]fluorinated α or β-aminoesters by deoxyradiofluorination using [18F]fluoride. The method involved the

BTK INHIBITORS

Provided are Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.