2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide

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Chemical Name:2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide
CAS No.:1032186-06-3
Molecular Formula:C₂₂H₂₄ClN₅O
Molecular Weight:409.918
Hs Code.:

Synonyms:2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide

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Chemical Property of 2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide

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Technology Process of 2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide

There total 4 articles about 2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1311992-47-8
2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate

: 142-84-7
di-n-propylamine

: 1032186-06-3
2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide

Guidance literature:: 2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

di-n-propylamine; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ja204016e

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1032186-06-3
2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: scandium tris(trifluoromethanesulfonate) / methanol / 1 h / 20 °C

2.1: dichloromethane / 1 h / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Ugi reaction / 1.2: Ugi reaction;
DOI:10.1021/ja204016e

Reference yield:

: 42182-27-4
4-cyanopyridin-2-amine

: 1032186-06-3
2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: scandium tris(trifluoromethanesulfonate) / methanol / 1 h / 20 °C

2.1: dichloromethane / 1 h / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Ugi reaction / 1.2: Ugi reaction;
DOI:10.1021/ja204016e