2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate

Base Information

Chemical Name:2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate
CAS No.:1311992-47-8
Molecular Formula:C₂HF₃O₂*C₁₆H₁₁ClN₄O₂
Molecular Weight:440.766
Hs Code.:

Synonyms:2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate

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Chemical Property of 2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate

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Technology Process of 2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate

There total 2 articles about 2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1032186-22-3
tert-butyl 2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetate

: 76-05-1
trifluoroacetic acid

: 1311992-47-8
2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ja204016e

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1311992-47-8
2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: scandium tris(trifluoromethanesulfonate) / methanol / 1 h / 20 °C

2: dichloromethane / 1 h / 20 °C

With scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane; 1: Ugi reaction / 1: Ugi reaction;
DOI:10.1021/ja204016e

Reference yield: 61.0%

: 1311992-47-8
2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate

: 142-84-7
di-n-propylamine

: 1032186-06-3
2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)-N,N-dipropylacetamide

Guidance literature:: 2-(2-(4-chlorophenyl)-7-cyanoimidazo[1,2-a]pyridin-3-ylamino)acetic acid trifluoroacetate; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

di-n-propylamine; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ja204016e