4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid

Base Information

Chemical Name:4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid
CAS No.:1443431-25-1
Molecular Formula:C₁₆H₁₄ClF₂NO₄
Molecular Weight:357.741
Hs Code.:

Synonyms:4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid

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Chemical Property of 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid

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Technology Process of 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid

There total 8 articles about 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443432-66-3
ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate

: 1443431-25-1
4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid

Guidance literature:: ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=1;

Reference yield:

: 2402-77-9
2,3-dichloro-pyridine

: 1443431-25-1
4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 5 - 20 °C

1.2: 18 h / Reflux

2.1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / n-heptane / Inert atmosphere

3.1: peracetic acid / water; acetic acid / 4 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

5.2: pH 1

With peracetic acid; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; water; sodium hydride; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; sodium hydroxide; In tetrahydrofuran; methanol; n-heptane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1344997-94-9
3-chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1443431-25-1
4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: peracetic acid / water; acetic acid / 4 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

3.2: pH 1

With peracetic acid; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide;