ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate

Base Information

Chemical Name:ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate
CAS No.:1443432-66-3
Molecular Formula:C₁₈H₁₈ClF₂NO₄
Molecular Weight:385.795
Hs Code.:

Synonyms:ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate

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Chemical Property of ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate

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Technology Process of ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate

There total 6 articles about ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355066-41-9
5-chloro-6-(1-propan-2-yloxy)-3-pyridinol

: 1355488-98-0
ethyl 4-(bromomethyl)-2,5,difluorobenzoate

: 1443432-66-3
ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;

Reference yield:

: 103877-80-1
2,5-difluoro-4-methyl-benzoic acid

: 1443432-66-3
ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 18 h / 70 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / 1,2-dichloro-ethane / 70 °C

3: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; thionyl chloride; potassium carbonate; dibenzoyl peroxide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 2402-77-9
2,3-dichloro-pyridine

: 1443432-66-3
ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 5 - 20 °C

1.2: 18 h / Reflux

2.1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / n-heptane / Inert atmosphere

3.1: peracetic acid / water; acetic acid / 4 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With peracetic acid; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; sodium hydride; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; n-heptane; water; acetic acid; N,N-dimethyl-formamide;