N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline
• CAS No.: 744253-75-6
• Molecular Formula: C₁₉H₂₆N₂O₆
• Molecular Weight: 378.425

Synonyms:N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Chemical Property of N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

There total 2 articles about N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (13726-69-7,946610-68-0) + 3,5-dimethylphenyl isocyanate (54132-75-1) → N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline (744253-75-6)

Guidance literature:

With pyridine; at 115 ℃; for 22h;

DOI:10.1055/s-2004-822384

Reference yield: 90.0%

N-α-tert-butyloxycarbonyl-trans-4-hydroxy-L-proline dicyclohexylammonium salt + 3,5-dimethylphenyl isocyanate (54132-75-1) → N,N'-bis(3,5-dimethylphenyl)urea + N-(3,5-dimethylphenyl)-N,N'-dicyclohexylurea + N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline (744253-75-6)

Guidance literature:

With pyridine; for 22h; Heating;

DOI:10.1055/s-2004-822384

Reference yield: 73.0%

N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline (744253-75-6) → (4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline (744253-84-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1055/s-2004-822384

upstream raw materials:

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

3,5-dimethylphenyl isocyanate

Downstream raw materials:

N-(tert-butoxycarbonyl)-N'-(3,5-dimethylphenyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-prolinamide

(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 744253-75-6 N-(tert-butoxycarbonyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Send

Send

Metric Ton KG G Pound L ML

Send

Send