4-AMINO-6-HYDROXYPYRAZOLO[3,4-D]PYRIMIDINE

Base Information

• Chemical Name: 4-AMINO-6-HYDROXYPYRAZOLO[3,4-D]PYRIMIDINE
• CAS No.: 5472-41-3
• Molecular Formula: C5H5 N5 O
• Molecular Weight: 151.128
• Hs Code.: 2933990090
• Mol file: 5472-41-3.mol

Synonyms:1H-Pyrazolo[3,4-d]pyrimidin-6-ol,4-amino- (6CI,8CI); 1H-Pyrazolo[3,4-d]pyrimidine, 4-amino-, 6-oxide (7CI);6H-Pyrazolo[3,4-d]pyrimidin-6-one, 4-amino-1,5-dihydro- (9CI);4-Amino-6-hydroxypyrazolo[3,4-d]pyrimidine;4-Amino-6-oxopyrazolo[3,4-d]pyrimidine; NSC 28415

Chemical Property of 4-AMINO-6-HYDROXYPYRAZOLO[3,4-D]PYRIMIDINE

Chemical Property:

• Appearance/Colour: beige powder
• Vapor Pressure: 3.98E-05mmHg at 25°C
• Melting Point: 320 °C
• Refractive Index: 1.9000 (estimate)
• Boiling Point: 351.9 °C at 760 mmHg
• PKA: 4.65±0.40(Predicted)
• Flash Point: 166.6 °C
• PSA: 100.71000
• Density: 2.19 g/cm³
• LogP: 0.22190

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-6-hydroxypyrazolo[3,4-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 24/25-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-6-HYDROXYPYRAZOLO[3,4-D]PYRIMIDINE

There total 6 articles about 4-AMINO-6-HYDROXYPYRAZOLO[3,4-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-Dihydro-4-thioxo-1H-pyrazolo[3,4-d]pyrimidin-6(7H)-one (5334-33-8,132786-97-1) → 4-amino-1,7-dihydro-pyrazolo[3,4-d]pyrimidin-6-one (5472-41-3)

Guidance literature:

With ethanol; ammonia; at 143 ℃;

DOI:10.1021/ja01594a046

Reference yield:

6-methylsulfanyl-1(2)H-pyrazolo[3,4-d]pyrimidin-4-ylamine (5444-29-1) → 4-amino-1,7-dihydro-pyrazolo[3,4-d]pyrimidin-6-one (5472-41-3)

Guidance literature:

With hydrogenchloride; dihydrogen peroxide;

DOI:10.1021/jo01110a615

Reference yield:

urea (57-13-6) → 4-amino-1,7-dihydro-pyrazolo[3,4-d]pyrimidin-6-one (5472-41-3)

Guidance literature:

at 180 - 200 ℃;

DOI:10.1021/ja01585a023

upstream raw materials:

6-methylsulfanyl-1⁽²⁾H-pyrazolo[3,4-d]pyrimidin-4-ylamine

4,5-Dihydro-4-thioxo-1H-pyrazolo[3,4-d]pyrimidin-6(7H)-one

urea

4-chloro-6-methylmercapto-1H-pyrazolo[3,4-d]pyrimidine