N-{4-[3-(4-Amino-1-oxo-1H-1λ⁴-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine

Base Information

• Chemical Name: N-{4-[3-(4-Amino-1-oxo-1H-1λ⁴-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine
• CAS No.: 81074-55-7
• Molecular Formula: C₁₂H₁₂N₈OS₂
• Molecular Weight: 348.412

Synonyms:N-{4-[3-(4-Amino-1-oxo-1H-1λ⁴-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine

Chemical Property of N-{4-[3-(4-Amino-1-oxo-1H-1λ⁴-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine

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Technology Process of N-{4-[3-(4-Amino-1-oxo-1H-1λ⁴-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine

There total 4 articles about N-{4-[3-(4-Amino-1-oxo-1H-1λ⁴-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-guanidino-4-(3-nitrophenyl)thiazole (83831-32-7) → N-{4-[3-(4-Amino-1-oxo-1H-1λ4-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine (81074-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / H₂, concd. HCl / 10percent Pd/C / ethanol / 4 h / 2585.7 Torr

2: methanol / Ambient temperature

3: 2 M ammonia / ethanol / Ambient temperature

With hydrogenchloride; ammonium hydroxide; hydrogen; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jm00356a005

Reference yield:

3'-nitro-2-bromoacetophenone (2227-64-7) → N-{4-[3-(4-Amino-1-oxo-1H-1λ4-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine (81074-55-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 59 percent / triethylamine / methanol / Ambient temperature

2: 85 percent / H₂, concd. HCl / 10percent Pd/C / ethanol / 4 h / 2585.7 Torr

3: methanol / Ambient temperature

4: 2 M ammonia / ethanol / Ambient temperature

With hydrogenchloride; ammonium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jm00356a005

Reference yield:

N-{4-[3-(4-Methoxy-1-oxo-1H-1λ4-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine (81074-36-4) → N-{4-[3-(4-Amino-1-oxo-1H-1λ4-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine (81074-55-7)

Guidance literature:

With ammonium hydroxide; In ethanol; Yield given; Ambient temperature;

DOI:10.1021/jm00356a005

upstream raw materials:

N-{4-[3-(4-Methoxy-1-oxo-1H-1λ⁴-[1,2,5]thiadiazol-3-ylamino)-phenyl]-thiazol-2-yl}-guanidine

2-guanidino-4-(3-aminophenyl)thiazole

2-guanidino-4-(3-nitrophenyl)thiazole

3'-nitro-2-bromoacetophenone

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