Technology Process of tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(1,3-oxazol-4-ylmethyl)piperidin-3-yl}carbamate
There total 9 articles about tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(1,3-oxazol-4-ylmethyl)piperidin-3-yl}carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate; 1,3-oxazole-4-carboxaldehyde;
With
acetic acid;
In
ISOPROPYLAMIDE;
for 4h;
With
sodium tris(acetoxy)borohydride;
In
ISOPROPYLAMIDE;
for 18h;
With
methanol;
In
ISOPROPYLAMIDE;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ammonium acetate / ethanol / 16 h / Reflux
2.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C
2.2: 15 h / 0 - 20 °C
3.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C
3.2: 3 h
3.3: 0.17 h
4.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C
5.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C
5.2: 0.75 h / 0 °C
6.1: acetic acid / ISOPROPYLAMIDE / 4 h
6.2: 18 h
With
sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; ammonium acetate; acetic acid;
nickel (II) chloride hexahydrate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C
1.2: 15 h / 0 - 20 °C
2.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C
2.2: 3 h
2.3: 0.17 h
3.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C
4.2: 0.75 h / 0 °C
5.1: acetic acid / ISOPROPYLAMIDE / 4 h
5.2: 18 h
With
sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; acetic acid;
nickel (II) chloride hexahydrate;
In
tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;