Oxazole-4-carbaldehyde

Base Information

• Chemical Name: Oxazole-4-carbaldehyde
• CAS No.: 118994-84-6
• Molecular Formula: C4H3NO2
• Molecular Weight: 97.0733
• Hs Code.: 2934999090
• Mol file: 118994-84-6.mol

Synonyms:4-Formyloxazole;1,3-Oxazole-4-carboxaldehyde;4-Oxazolecarboxaldehyde;

Chemical Property of Oxazole-4-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.723mmHg at 25°C
• Melting Point: 57-61 °C
• Refractive Index: 1.518
• Boiling Point: 184.7 °C at 760 mmHg
• PKA: -1.49±0.10(Predicted)
• Flash Point: 65.5 °C
• PSA: 43.10000
• Density: 1.258 g/cm³
• LogP: 0.48710
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Oxazole-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxazole-4-carbaldehyde

There total 4 articles about Oxazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-hydroxymethyl-1,3-oxazole (155742-48-6) → 1,3-oxazole-4-carboxaldehyde (118994-84-6)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -63 ℃; for 0.25h;

4-hydroxymethyl-1,3-oxazole; In dichloromethane; at -63 ℃; for 1.25h;

Reference yield: 81.0%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) → 1,3-oxazole-4-carboxaldehyde (118994-84-6)

Guidance literature:

With diisobutylaluminium hydride; Inert atmosphere;

DOI:10.3762/bjoc.10.230

Reference yield: 70.0%

1-Oxazol-4-yl-propane-1,2,3-triol (130551-96-1) → 1,3-oxazole-4-carboxaldehyde (118994-84-6)

Guidance literature:

With sodium periodate; silica gel;

DOI:10.1021/jo00001a087

upstream raw materials:

1-Oxazol-4-yl-propane-1,2,3-triol

oxazole-4-carboxylic acid ethyl ester

4-hydroxymethyl-1,3-oxazole

N-methoxy-N-methyloxazole-4-carboxamide

Downstream raw materials:

C₁₃H₁₂ClNO₃

C₁₇H₁₉NO₃

C₁₂H₁₇NO₃

C₁₂H₁₁NO₃

Refernces

• 1、 He, Tian-Jun,Zhu, Shijun,Lu, Xiao-Wei,Wu, Yikang,Li, Yan. "Absolute configurations of melanoxadin, MR-93A, melanoxazal, and MR-93B". . p. 647 - 654. Retrieved 2015/01/30.
• 2、 Reeves, Jonathan T.,Song, Jinhua J.,Tan, Zhulin,Lee, Heewon,Yee, Nathan K.,Senanayake, Chris H.. "A general synthesis of substituted formylpyrroles from ketones and 4-formyloxazole". . p. 1875 - 1878. Retrieved 2008/02/04.