(S)-2-(4-Fluoro-phenyl)-5-oxo-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Base Information

Chemical Name:(S)-2-(4-Fluoro-phenyl)-5-oxo-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide
CAS No.:903512-73-2
Molecular Formula:C₂₀H₁₆F₇NO₂
Molecular Weight:435.341
Hs Code.:

Synonyms:(S)-2-(4-Fluoro-phenyl)-5-oxo-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

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Chemical Property of (S)-2-(4-Fluoro-phenyl)-5-oxo-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Chemical Property:

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Technology Process of (S)-2-(4-Fluoro-phenyl)-5-oxo-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

There total 5 articles about (S)-2-(4-Fluoro-phenyl)-5-oxo-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913537-21-0
(S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

: 903512-73-2
(S)-2-(4-Fluoro-phenyl)-5-oxo-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In diethyl ether; at -78 - 20 ℃;
DOI:10.1021/jm060439n

Reference yield:

: 691875-76-0
(S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

: 903512-73-2
(S)-2-(4-Fluoro-phenyl)-5-oxo-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: BH₃ / tetrahydrofuran / 20 °C

1.2: 2.65 g / aq. NaBO₃ / 2 h / 20 °C

2.1: oxalyl chloride; Et₃N; DMSO / diethyl ether / -78 - 20 °C

With oxalyl dichloride; borane; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; 2.1: Swern oxidation;
DOI:10.1021/jm060439n

Reference yield:

: 51230-93-4
2-(4-fluorophenyl)pent-4-enoic acid

: 903512-73-2
(S)-2-(4-Fluoro-phenyl)-5-oxo-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: (S)-(-)-α-methylbenzylamine / ethyl acetate

2.1: 9.41 g / EDC; HOBt / CH₂Cl₂ / 20 °C

3.1: BH₃ / tetrahydrofuran / 20 °C

3.2: 2.65 g / aq. NaBO₃ / 2 h / 20 °C

4.1: oxalyl chloride; Et₃N; DMSO / diethyl ether / -78 - 20 °C

With oxalyl dichloride; (S)-1-phenyl-ethylamine; borane; benzotriazol-1-ol; dimethyl sulfoxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; 4.1: Swern oxidation;
DOI:10.1021/jm060439n