(S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Base Information

Chemical Name:(S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide
CAS No.:913537-21-0
Molecular Formula:C₂₀H₁₈F₇NO₂
Molecular Weight:437.357
Hs Code.:

Synonyms:(S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Suppliers and Price of (S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

There total 4 articles about (S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691875-76-0
(S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

: 913537-21-0
(S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: (S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide; With borane; In tetrahydrofuran; at 20 ℃;

With sodium perborate; at 20 ℃; for 2h;
DOI:10.1021/jm060439n

Reference yield:

: 51230-93-4
2-(4-fluorophenyl)pent-4-enoic acid

: 913537-21-0
(S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: (S)-(-)-α-methylbenzylamine / ethyl acetate

2.1: 9.41 g / EDC; HOBt / CH₂Cl₂ / 20 °C

3.1: BH₃ / tetrahydrofuran / 20 °C

3.2: 2.65 g / aq. NaBO₃ / 2 h / 20 °C

With (S)-1-phenyl-ethylamine; borane; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm060439n

Reference yield:

: 494802-92-5
(S)-2-(4-fluorophenyl)-4-pentenoic acid

: 913537-21-0
(S)-2-(4-Fluoro-phenyl)-5-hydroxy-pentanoic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 9.41 g / EDC; HOBt / CH₂Cl₂ / 20 °C

2.1: BH₃ / tetrahydrofuran / 20 °C

2.2: 2.65 g / aq. NaBO₃ / 2 h / 20 °C

With borane; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm060439n