phenyl 3-hydroxymethylpicolinanilide

Base Information

• Chemical Name: phenyl 3-hydroxymethylpicolinanilide
• CAS No.: 122706-45-0
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.25
• Mol file: 122706-45-0.mol

Synonyms:phenyl 3-hydroxymethylpicolinanilide

Chemical Property of phenyl 3-hydroxymethylpicolinanilide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of phenyl 3-hydroxymethylpicolinanilide

There total 4 articles about phenyl 3-hydroxymethylpicolinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5,6-dihydro-5-hydroxy-6-phenyl-7H-pyrrolo<3,4-b>pyridin-7-one (122706-49-4) → phenyl 3-hydroxymethylpicolinanilide (122706-45-0)

Guidance literature:

With potassium borohydride; In methanol; Ambient temperature;

DOI:10.1080/00397919408010186

Reference yield: 35.0%

6-Phenylpyrrolo<3,4-b>pyridine-5,7(6H)-dione (6538-81-4) → phenyl 3-hydroxymethylpicolinanilide (122706-45-0) + 2-Hydroxymethyl-N-phenyl-nicotinamide (122706-39-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; r.t., 15 min; 50 deg C, 1.5 h;

DOI:10.1246/bcsj.62.1205

Reference yield:

6-Phenylpyrrolo<3,4-b>pyridine-5,7(6H)-dione (6538-81-4) → phenyl 3-hydroxymethylpicolinanilide (122706-45-0) + 2-Hydroxymethyl-N-phenyl-nicotinamide (122706-39-2) + 5,6-dihydro-5-hydroxy-6-phenyl-7H-pyrrolo<3,4-b>pyridin-7-one (122706-49-4) + 6,7-dihydro-7-hydroxy-6-phenyl-5H-pyrrolo<3,4-b>pyridin-5-one (122706-33-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 2h; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

upstream raw materials:

6-Phenylpyrrolo<3,4-b>pyridine-5,7(6H)-dione

5,6-dihydro-5-hydroxy-6-phenyl-7H-pyrrolo<3,4-b>pyridin-7-one

N-phenylpicolinamide

Downstream raw materials:

(3-Hydroxymethyl-pyridin-2-yl)-(2-methoxy-phenyl)-methanone