122706-49-4Relevant academic research and scientific papers
Novel synthesis of aza-phthalimidine hydroxylactams
Fan, Bolin,Liu, Zenglu,Tang, Mei,Xu, Yun,Tang, Xiaowei,Mao, Zhenmin
, p. 3231 - 3242 (2008/12/23)
A novel and convenient synthetic route for preparing aza-phthalimidine hydroxylactams (5a-j) by N-bromosuccinimide (NBS) was developed. This method involved the substitution reactions of substrates (3a-j) with NBS via unstable intermediate bromides (4a-j) rapidly hydrolyzed into hydroxyl products in the course of the workup process. Copyright Taylor & Francis Group, LLC.
Application of organolithium and related reagents in synthesis; Part 17: Synthesis of azaisoindolo[2,1-a]quinoline derivatives
Epsztajn, Jan,Grzelak, Renata,Jozwiak, Andrzej
, p. 1212 - 1216 (2007/10/03)
The synthesis of the 3-hydroxy-5(or 7)-azaisoindolin-1-ones and their conversion into 2-aryl-2,3-dihydro-3-oxo-1H-azaisoindole-1 acetic acids, and their subsequent cyclization via sequential treatment with oxalyl chloride and aluminium chloride as a way o
Application of organolithium and related reagents in synthesis. Part 15. A concise regiospecific conversion of picolinic- and isonicotinic acids into 2-benzoyl- and 4-benzoylnicotinic acids
Epsztajn,Jozwiak,Szczesniak
, p. 1789 - 1798 (2007/10/02)
The synthesis of the azaphthalides (7) and (8) and their conversion into the corresponding 2- and 4-benzoyl-3-hydroxymethylpyridines (9) and (10), very useful precursors of the 2- and 4-benzoylated nicotinic acids (11) and (12), as a way of regiospecific
Antihypertensive benzopyran derivatives
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, (2008/06/13)
Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.
Regioselective Formation of Hydroxy Lactams from Pyridine-2,3-dicarboximides and their Cyclodehydration to Pyridopyrrolo-fused Heterocyclic Systems
Hitchings, Gregory J.,Vernon, John M.
, p. 1757 - 1763 (2007/10/02)
Grignard reactions of pyridine-2,3-dicarboximides involve attack at the carbonyl group closer to the pyridine nitrogen atom to give 7-hydroxypyrrolopyridin-5(7H)-one derivatives.Reduction of the same imides with sodium borohydride gives mixtures of regiosomeric hydroxy lactams, in which the 7-hydroxypyrrolopyridin-5-ones are the major components.Hydroxy lactams derived by either of these two methods from pyridine-2,3-dicarboximides containing N-benzyl, N-2-phenylethyl, N-2-(indol-3-yl)ethyl, or N-biphenyl-2-yl substituents are cyclised by heating in trifluoroacetic or polyphosphoric acid to give derivatives of new pyridopyrrolo-fused heterocyclic systems.
Magnesium Ion Assisted Highly Regio- and Chemoselective Reduction of 5H-Pyrrolopyridine-5,7(6H)-diones with Sodium Borohydride. A Convenient Synthesis of 6,7-Dihydro-7-hydroxy-5H-pyrrolopyridin-5-ones
Goto, Takehiko,Konno, Michio,Saito, Minoru,Sato, Ryu
, p. 1205 - 1210 (2007/10/02)
6-Substituted and unsubstituted 6,7-dihydro-7-hydroxy-5H-pyrrolopyridin-5-ones were predominantly obtained in excellent yield by the reduction of the corresponding 5,7-diones with sodium borohydride in the presence of Mg ion at 0 deg C.The highly r
