N-Phenylpicolinamide

Base Information

• Chemical Name: N-Phenylpicolinamide
• CAS No.: 10354-53-7
• Molecular Formula: C12H10N2O
• Molecular Weight: 198.224
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20427270
• Nikkaji Number: J589.167A
• Wikidata: Q82239964
• ChEMBL ID: CHEMBL2046767
• Mol file: 10354-53-7.mol

Synonyms:N-phenylpicolinamide

Chemical Property of N-Phenylpicolinamide

Chemical Property:

• Melting Point: 74-75°C
• Boiling Point: 265.8±13.0 °C(Predicted)
• PKA: 11.91±0.70(Predicted)
• PSA: 45.48000
• Density: 1.227±0.06 g/cm3(Predicted)
• LogP: 2.71790
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone, Benzene, Chloroform (Slightly), Dichloromethane, Ether, Ethyl Acetate (
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 198.079312947
• Heavy Atom Count: 15
• Complexity: 212

Purity/Quality:

98%,99%, ^*data from raw suppliers

Picolinic Anilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC(=O)C2=CC=CC=N2
• Uses: Picolinic Anilide (cas# 10354-53-7) is a compound useful in organic synthesis.

Technology Process of N-Phenylpicolinamide

There total 39 articles about N-Phenylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl pyridine-2-carboxylate (2459-07-6,260998-83-2) + aniline (62-53-3) → N-phenylpicolinamide (10354-53-7)

Guidance literature:

With sodium t-butanolate; In neat (no solvent); at 20 ℃; for 1h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1039/d1gc00720c

Reference yield: 96.0%

2-Hydroxymethylpyridine (586-98-1) + aniline (62-53-3) → N-phenylpicolinamide (10354-53-7)

Guidance literature:

With oxygen; lithium hydroxide; In water; at 50 ℃; for 12h;

DOI:10.1002/anie.201102374

Reference yield: 92.0%

2-picolinoyl chloride hydrochloride (39901-94-5) + aniline (62-53-3) → N-phenylpicolinamide (10354-53-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

upstream raw materials:

2-Picolinic acid

aniline

pyridine-2-carbonyl azide

2-picolinoyl chloride hydrochloride

Downstream raw materials:

2,2'-bis-phenylcarbamoyl-1,1'-ethanediyl-bis-pyridinium; dibromide

N-phenyl-pyridine-2-carbonimidic acid anilide

(E)-1,2-diphenyl-ethene

3-[Hydroxy-(4-methoxy-phenyl)-methyl]-pyridine-2-carboxylic acid phenylamide