tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate

Base Information

Chemical Name:tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate
CAS No.:1227062-86-3
Molecular Formula:C₂₆H₃₆BrNO₂
Molecular Weight:474.481
Hs Code.:

Synonyms:tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate

Suppliers and Price of tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate

There total 7 articles about tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: tert-butyl (E)-7-bromohept-2-enoate

: 1227062-86-3
tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate

: 151379-88-3
tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

tert-butyl (E)-7-bromohept-2-enoate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2011.09.038

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 1227062-86-3
tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate

: 151379-88-3
tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

1.3: 20 °C

2.1: carbon tetrabromide / dichloromethane / 1 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; carbon tetrabromide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2011.09.038

Reference yield:

: 542-28-9,26354-94-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 1227062-86-3
tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-bromoheptanoate

: 151379-88-3
tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

1.3: 20 °C

2.1: carbon tetrabromide / dichloromethane / 1 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; carbon tetrabromide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2011.09.038